C4B and endocarditis: Adhesion is the first step in biofilm formation, and several proteins have a vital role, such as endocarditis and biofilm-associated pilus (ebp) ABC, aggregation substance (Agg), SagA-like protein B (salB) and esp(Ch’ng, Chong et al. 2019, Geraldes, Tavares et al. 2022).