Muthuswamy et al. (15) identified CXCR6 as a critical regulator of residency and persistence of memory CD8+ T-cell responses in the ovarian tumor microenvironment, supporting development of CXCR6/CXCL16-targeted therapeutic approaches to enhance antitumor tissue-resident memory retention within the tumor microenvironment. This evidence concerns the gene CXCR6 and ovarian neoplasm.