PPARD and neoplasm: Hence, in this study, we aimed to examine whether transgenic PPARδ expression in VGPCs orchestrates the gastric iTME to promote GAC tumorigenesis via upregulating the Ccl20/Ccr6 axis; whether specially targeted inhibition of PPARδ suppresses GAC tumorigenesis by inhibiting Ccl20/Ccr6 axis to significantly reverse the iTME; and whether circulating CCL20 in sera can serve as a potential biomarker for the early detection and tumor progression of GAC.