Actually, the LoD values achieved with AD immunosensors are often remarkably improved as compared with those of the corresponding well-established ELISA methods; for instance, an LoD of 0.42 pg mL−1 has been achieved with the electrochemical AD-immunosensor detecting the SSc-associated AD biomarker, oncostatin M receptor (OSMR), instead of the 312.50 pg mL−1 LoD value reported for the corresponding gold-standard ELISA method [41]. This evidence concerns the gene OSMR and systemic sclerosis.