As the hub gene identified in response to acute AE combined with PI in the YM, DDIT3 is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, promotes apoptosis, and plays a crucial role in endoplasmic reticulum stress-induced apoptosis and autophagy, host innate immunity repression, and viral infection facilitation [82]. Here, DDIT3 is linked to viral infectious disease.