For instance, in APP/PSEN1 transgenic AD model mice, it was shown that cognitive dysfunction and hippocampal neuroinflammatory responses are decreased by Bilberry anthocyanins, and the microglia phagocytosis of beta-amyloid protein plaques is improved by upregulation of the TREM2/TYROBP/CD33 signaling pathway [22]. This evidence concerns the gene TREM2 and Alzheimer disease.