In a more recent study, Cyanidin-3-O-glucoside (C3G), a phytochemical found in fruits and vegetables, could also reduce neuroinflammation and reactive oxygen species (ROS), and enhance microglial Aβ42 phagocytosis through the upregulation of TREM2 in a mouse model of AD [23]. This evidence concerns the gene TREM2 and Alzheimer disease.