Additionally, epigallocatechin gallate (EGCG), a tea phytochemical, reduces Aβ (1–40), the amyloid precursor protein (APP), and neuronal apoptosis, and activates TrkA signaling (the receptor for BDNF) in the APP/PS1 mice model of AD associated with cognitive improvement [75]. The gene discussed is APP; the disease is Alzheimer disease.