PRLR and Hyperglycemia: Also, streptozotocin (STZ)-induced diabetes in Prlr-KO adult mice (5–7 weeks old) resulted in increased hyperglycemia and glucose intolerance and lower insulin levels than STZ-induced diabetic WT mice [24], whereas no abnormalities in glucose and insulin levels were observed in non-diabetic Prlr-KO mice compared to their WT counterparts.