BBS2 and obesity disorder: Since obesity development manifested in the intensified hyperplasia and hypertrophy of adipocytes, and aberrant lipid storage, lipogenesis, and lipogenesis processes, it is suggested that BBS obesity is not only related to the central regulation of appetite and satiety mechanisms in the hypothalamus but might be partly due to a direct role of BBS genes in physiological and pathophysiological mechanisms that underlie adipose tissue formation relevant to obesity.