For example, the SNP rs17782313, located 188 kb downstream of the MC4R gene, was found to be significantly associated with a higher BMI, higher fat mass, and elevated risk of common obesity in various populations with different genetic backgrounds, including Caucasians, Mexican, Chinese, and Iranian [206,207,208,209,210,211,212,213,214]. Here, MC4R is linked to obesity due to melanocortin 4 receptor deficiency.