Moreover, we have shown that Bbs4 plays a role in the ER stress induced in early cell differentiation in vitro in both adipocytes and neuronal cell models [252,253], highlighting that BBS obesity is not only an outcome of a decreased satiety but is mediated in part by peripheral mechanisms, such as accelerated hyperplasia and hypertropia, and the dysfunction or abnormalities of adipocytes. The gene discussed is BBS4; the disease is obesity disorder.