TLR4 and obesity due to melanocortin 4 receptor deficiency: This study aims to preliminarily reveal the link between TLR4 rs1928295 gene polymorphism and Chinese Han school-age (7–12 years) children’s overweight/obesity, and further explore the interaction between TLR4 rs1928295 polymorphism, macronutrient intake, and dietary patterns on the risk of overweight/obesity.