Whereas the first objective of this study was to show that MDD patients without comorbidities had an elevated CRP level compared to the CTRLs, the second goal was to assess whether their diet, through the balance of the pro-inflammatory (SFAs, TFAs, n-6 PUFA, and sugars) and anti-inflammatory nutrients (AGMI, n-3 PUFA, DFs, and Aos), but also the glycemic load and the AGE level, could act as a risk factor. Here, CRP is linked to major depressive disorder.