CYBB and brain infarction: In another study, however, rats undergoing ischemic brain injury/reperfusion (CI/R) treated with Andro showed decreased cerebral infarction, reduced superoxide anion and nitrotyrosine, reduced expression of gp91phox/NOX2, IL-1β and hypoxia inducible factor (HIF), as well as reduced NFkB p65, thus confirming the protective effects of Andro in counteracting an ischemic attack [73].