NR1H4 and metabolic disease: The metabolite–disease interaction network showed that urine creatinine, which was reduced due to FXR inactivation was associated with neurological disorders (e.g., Canavan disease and schizophrenia), urinary disorders (e.g., Bartter syndrome, type 2, antenatal and maple syrup urine disease), and metabolic disorders (dimethylglycine dehydrogenase deficiency) (Supplementary Figure S5B).