Also, current research aims at the involvement of gender characteristics, such as the influence of sex hormones (estrogen and testosterone), in the intestinal microenvironment, thereby imprinting the biological picture of SLE, but also the ability of the Ruminococcus gnavus strain from subjects with lupus to produce alteration of intestinal permeability through the action on zonulin, at the same time documenting the reversal of the process upon initiation of treatment with larazotide acetate (zonulin antagonist) [96,97]. The gene discussed is HP; the disease is systemic lupus erythematosus.