A new study suggests that taxifolin prevents skin carcinogenesis through a novel molecular mechanism, where NRF2 is activated by inhibiting the protein expression of epigenetic modification enzymes such as DNMT1, DNMT3a, and DNMT3b, which in turn reduces DNA methylation in CpGs in the NRF2 gene promoter region in JB6 P+ Cells [37]. Here, NFE2L2 is linked to neoplasm.