Another study designed to determine sulforaphane’s neuroprotective effects in the disease model of Alzheimer’s disease revealed that sulforaphane upregulated NRF2 expression and promoted NRF2 nuclear translocation via decreasing DNA methylation levels of the NRF2 promoter in mouse neuroblastoma Appswe cells. The gene discussed is NFE2L2; the disease is early-onset autosomal dominant Alzheimer disease.