SFN was also reported to inhibit protein levels of DNMT1, reduce NRF2 promoter DNA methylation, and increase mRNA and protein levels of NRF2, which resulted in the prevention of the neoplastic transformation of TSA-induced Caco-2 cells, which suggests that NRF2 might have a chemopreventive effect against human colon cancer. This evidence concerns the gene NFE2L2 and malignant colon neoplasm.