STAT3 and colorectal carcinoma: In order to better understand the role of STAT-3 in gut-microbiota dysbiosis, researchers evaluated through immunohistochemical techniques the levels of phosphorylated STAT-3 (pSTAT-3) expression in eighteen colorectal cancer (CRC) samples and in the paracancerous tissues and demonstrated that more than 72% of CRC samples had an increased expression of pSTAT-3, especially localized in the nucleus.