In our results, we have shown that a large number of genes showing regulation in response to both LA and AA formed immune-modulatory clusters, e.g., cellular response to TGF-β and TNF, cytokine activity and regulation of the MAPK cascade and leukocyte migration/chemotaxis and differentiation, regulation of IFN-γ and IL-17 signalling, which may be related not only to acne but also to other inflammatory skin diseases [57,58,59]. Here, IFNG is linked to acne.