The extracellular signal-regulated kinase (ERK)1/2 and p38 mitogen-activated protein kinase (p38-MAPK) pathways are known to play a key role in cardiac fibroblast proliferation, and the dysregulation of these pathways has been linked to arrhythmias, myocardial infarction, hypertension, and heart failure. This evidence concerns the gene MAPK14 and hypertensive disorder.