In another study involving a mouse colorectal adenoma model, 6-shogaol treatment reversed the effect of Azoxymethane (AOM) and dextran sulphate sodium (DSS) in animal models by reducing colon weight, colon length, and the levels of NO, myeloperoxidase (MPO), H2O2, and TNF-α [81]. The gene discussed is MPO; the disease is colorectal adenoma.