Moving to inflammation, by amplifying STAT6- and STAT3-driven transcription [45,47], PARP14 is involved in Th2/Th17 signaling in immune response [55], and elevated PARP14 expression is found in tissues derived from patients with idiopathic pulmonary fibrosis, atopic dermatitis and psoriasis, as well as in epithelial and inflammatory cells. This evidence concerns the gene PARP14 and atopic eczema.