Olaparib-based SK-575 (21, Figure 12A) [142] emerged as the most potent and efficacious degrader reported to date that achieved DC50 values in the picomolar range (228 pM to 578 pM) in a panel of five different cancer cell lines and effectively induced PARP1 degradation in SW620 xenograft tumor tissues in mice with the effect persisting for >24 h. Here, PARP1 is linked to cancer.