MAPT and early-onset autosomal dominant Alzheimer disease: It is now thought that there are two different types of interactions: major physical interactions between the two proteins at the synapse, or indirect interactions caused by Aβ and tau’s effects on neuronal physiology (activating kinases, preventing tau degradation, regulating excitability and gene expression, and activating glia) in slowing the progression of Alzheimer’s disease [53].