The major immunosuppressive cells in the TME of TNBC include myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) with an M2 phenotype, tumor-associated neutrophils (TANs) with an N2 phenotype, regulatory T (Treg) cells, and CD4+ helper T (Th) cells. Here, CD4 is linked to neoplasm.