CTG triplet amplification in 3′-UTR may occur in dystrophia myotonica protein kinase (DMPK) gene, and alternative splicing of junctophilin (JPH) gene exon 2a and ataxin8 (ATXN8) gene, which can, respectively, result in Muscular dystrophy type 1 (DM1), Huntington disease-like 2 (HDL2), and Spinocerebellar Ataxia 8 (SCA8). This evidence concerns the gene ATXN8 and Huntington disease-like 2.