In addition to NF-κB and Nrf2, mitogen-activated protein kinases (MAPKs) signaling pathways, such as Janus kinase/signal transducer and activator of transcription (Jak/STAT), cyclic-AMP response element-binding protein (CREB), phosphatidylinositol-3-kinase/serine-threonine kinase AKT (PI3K/Akt), are involved in liver cancer development and inflammation responses. This evidence concerns the gene CREB1 and liver cancer.