Behaving as the canonical STAT3 inhibitor, napabucasin attenuated the stemness of breast cancer stemness [32] and another type of cancer [30] and decreased stemness marker expression, colony formation ability, and aldehyde dehydrogenase (ALDH) activity of MCF7-R, which exhibited a higher stemness to MCF7 cells. The gene discussed is STAT3; the disease is cancer.