NFKB1 and metabolic dysfunction-associated steatotic liver disease: It has been shown that naringenin reduces methionine choline diet-induced NAFLD in mice through its anti-inflammatory properties by suppressinginterleukin-1β (IL-1β) expression and downregulating the NLRP3/NF-κB pathway in KC and hepatocytes, thereby attenuating the inflammatory response in the liver [50].