ERN1 and metabolic dysfunction-associated steatotic liver disease: Curcumin has also been found to increase the expression of phosphorylated serine-threonine protein kinase (pAKT) and P13K protein, protecting LO2 cells from oleic acid (OA)-induced NAFLD, improving glucose uptake in hepatocytes, with curcumin also reducing NO and ROS levels via Nrf2 signaling [107].