SREBF1 and fatty liver disease: The mechanism is based on the fact that curcumin reverses the expression of cytochrome P4503A (CYP3A) and cytochrome P4507A (CYP7A) by regulating the LXR pathway, and reduces the expression of CD36, SREBP1c, and small heterodimer partner (SHP) by regulating the FAS and Nrf2 pathways, thereby lowering hepatic steatosis [102].