PEBP1 and atherosclerosis: Additionally, it was reported that PC-PLC activities are mediated by PEBP1, a protein inhibitor of protein kinases, during atherosclerosis development, i.e., enhanced PC-PLC activities during elevated PEBP1 levels in atherosclerotic mice were reported, whereas PEBP1 downregulation was seen during PC-PLC inhibition [39].