HSPG2 and breast cancer: Similarly, a study showed that modulation of PC-PLC activities was able to regulate oncogenic HER2 and EGFR receptors: inhibition of PC-PLC reduced expression of HER2, induced HER2 internalization and reduced receptor recycling in SKBr3 cells and reduced membrane expression of EGFR and HER3 in SKBr3 cells, suggesting a strong relationship between PC-PLC signaling and its tumorous effects in breast cancer progression [17].