LOX and neoplasm: Several growth factors and enzymes overexpressed inside tumor tissues are also involved in the enhancement of tumoral ECM stiffness, wherein fibroblast activation protein α (FAP) and interleukin-1 and -6 (IL-1 and -6) activate the collagen synthesis by CAFs, and lysyl oxidase (LOX) is responsible for the chemical crosslinking of collagen [48,49,50,51].