Non-steroidal anti-inflammatory drugs (NSAIDs), selective cyclooxygenase-2 (COX-2) inhibitors, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor antagonists (ARA II), and diuretics, particularly loop diuretics, can impair renal function, which may increase the risk of lactic acidosis [4]. The gene discussed is PTGS2; the disease is lactic acidosis.