INS and Insulin resistance: Social stigma associated with injections is a contributing factor to psychological insulin resistance (which is defined as reluctance to use insulin in the treatment of diabetes) in patients and, consequently, poor glycemic control, along with an increased incidence of complications (including polyneuropathies, retinopathy, angiopathies, and sexual dysfunctions) [10,15,26,27,28,29,30,31,32].