LPAR3 and colorectal carcinoma: In colorectal cancer (CRC), however, suppressing 1-acylglycerol-3-phosphate O-acyltransferase 4 (Agpat4) can stimulate the production of LPA from CRC cells, and LPA polarizes macrophages into M1-like phenotypes through LPA1 and LPA3 [93].