UCHL1 and epilepsy: In human studies, Asadollahi and Simani, Yasak et al., and Elhady et al. [32,33,34] demonstrated elevated serum levels of UCHL-1 in children with epilepsy compared to healthy controls and found a correlation with seizure severity, suggesting the possibility of using UCH-L1 as a biomarker of neuronal damage to monitor disease progression and severity and for early identification of those with drug-resistant epilepsy and those who need epilepsy surgery.