ENO2 and Hypsarrhythmia: On the contrary, O’Regan et al. [25], in a group of 17 children/adolescents with different syndromic epilepsies and etiologies, found that the serum levels of NSE were significantly increased in those with continuous epileptiform discharges (e.g., hypsarrhythmia and electrical status epilepticus) compared to those without and normal controls.