Higher ICAM-1 serum levels were found in patients with SSc-ILD+ compared to those with SSc-ILD− (p < 0.01, Figure 2A, Table S1 (see Additional File S1)), although no significant differences were observed between these patients when E-selectin and ET-1 were evaluated (Figure 2A, Table S1 (see Additional File S1)). Here, EDN1 is linked to interstitial lung disease.