The importance of E-selectin, ICAM-1, and ET-1 is such that an expanding body of evidence demonstrates that increased levels of these molecules are associated with a wide variety of inflammatory and immune-mediated mechanisms, with the molecules being described as biomarkers of endothelial dysfunction in several disorders such as RA, SSc, systemic lupus erythematosus, spondyloarthropathies, psoriasis, and cerebral small vessel disease [1,2,24,25]. The gene discussed is EDN1; the disease is systemic sclerosis.