Furthermore, the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) mediated the activation of DRP1, and ATAD3A bound to ERK1/2 in the mitochondria of head and neck squamous cell carcinomas (HNSCC) cells activated the mitochondrial ERK1/2 signaling pathway (Figure 2 #2) [28,29]. The gene discussed is ATAD3A; the disease is head and neck squamous cell carcinoma.