KLK3 and neoplasm: In a multivariable analysis, GC (continuous variable, per 0.1 unit) was independently associated with distant metastasis (hazard ratio [HR], 1.17; 95% CI, 1.05–1.32; p = 0.006), PCSM (HR, 1.39; 95% CI, 1.20–1.63; p < 0.001) and OS (HR, 1.17; 95% CI, 1.06–1.29; p = 0.002) after adjusting for age, race/ethnicity, Gleason score, tumor stage, margin status, entry PSA and treatment arm.