Notably, upregulation of TIGIT has been observed in various malignancies, including melanoma, breast cancer, non-small-cell lung carcinoma (NSCLC), colon adenocarcinoma, gastric cancer, multiple myeloma (MM), and acute myeloid leukemia (AML) [114,115,116,117,118]. This evidence concerns the gene TIGIT and acute myeloid leukemia.