Bruck et al. observed TIM-3 overexpression on exhausted CD4+ and CD8+ T cells in untreated chronic myeloid leukemia (CML) patients and reported a correlation between PD-1+ TIM-3- CD8+ T cells and poor response to Tyrosine kinase inhibitors (TKIs) [93]. This evidence concerns the gene PDCD1 and chronic myelogenous leukemia, BCR-ABL1 positive.