ICAM1 and neoplasm: The expression of ICAM-1 determines the malignant potential of colorectal cancer; it is correlated with a worse prognosis [90,91], although there are also studies indicating that the membrane expression of this molecule correlates with better prognosis of colorectal cancer [92], which is explained by the possibility that ICAM-1 expression on the membrane of tumor cells stimulates the killing of tumor cells by cytotoxic lymphocytes, if they are present in the tumor microenvironment.