Chen et al. [176] demonstrated that Hairy and enhancer of split (Hes)-related with YRPW motif protein 2 (HEY2), an important transcription factor associated with Notch signaling, is a target of miR-98 and that inhibition of HEY2 by this microRNA resulted in inactivation of the Notch signalling pathway in AD mice. This evidence concerns the gene HEY2 and Alzheimer disease.