APP and Alzheimer disease: Magistri et al. [228] showed that EBF3-AS was upregulated in the brains of late-onset Alzheimer’s disease (LOAD) subjects, while Gu and colleagues [230] later corroborated this finding in the hippocampus of APP/PS1 AD mice and showed that it regulates EBF3 expression and, importantly, promotes Aβ-induced neuronal apoptosis in AD subjects.