It was initially known to play varying roles in processes that promote or inhibit the progression of various neoplastic diseases [247,248] but has recently been shown to play roles in Aβ-mediated neuroinflammation in AD, with studies revealing that the upregulation of MAGI2-AS3 promotes Aβ deposition, neuroinflammation, and neuronal loss [249]. Here, MAGI2 is linked to Alzheimer disease.