MiR-346, miR-101, miR-101a-3p, and miR-384 are known to inhibit APP production (and consequently, amyloid plaque generation) via their actions on either the 3′ or 5′ UTRs of the APP gene, and these microRNAs have been noted to be downregulated in animal models and AD subjects [146,147,148]. Here, APP is linked to Alzheimer disease.