SOCS1 and Alzheimer disease: This effect is associated with the direct inhibitory effects of miR-155 on the expression of SOCS-1 (suppressor of cytokine signalling 1), a potent inhibitor of inflammatory mechanisms, as observed in 3xTg AD mice used in this study, suggesting that miR-155 may be a potent neuroinflammation-based therapeutic target for AD [169].