Yamanaka and colleagues [223] showed that LRP1-AS, a conserved antisense lncRNA transcribed from the LRP1 gene locus, decreases LRP1 expression in the brains of AD subjects, possibly via epigenetic mechanisms, with consequent impairment of Aβ clearance, leading to amyloid plaque aggregation. The gene discussed is LRP1; the disease is Alzheimer disease.