In addition, in a mouse model of pancreatic ductal adenocarcinoma in which anorexia and muscle catabolism are seen, brain infiltrating immune cells were mostly neutrophils that expressed the chemokine receptor C-C chemokine receptor type 2 (CCR2) and blocking CCR2 decreased the brain infiltration of the immune cells and cachexia [23]. Here, CCR2 is linked to pancreatic ductal adenocarcinoma.