PINK1 and Parkinson disease: The roles of mitochondrial dysfunction as an initiator, propagator, or bystander in PD still remain poorly understood [6], but evidence points to mutations in the genes of putative kinase 1 (PINK1) and parkin (PRKN) in mediating mitochondrial damage and mitophagy and disruption of the subunits of mitochondrial complex I (MCI) [7].