AKT1 and breast carcinoma: Additionally, curcumin has demonstrated its capacity to modulate several pivotal signaling pathways implicated in breast cancer progression and development, such as JAK/STAT, NF-κB, WNT/β-catenin, PI3K/Akt/mTOR, MAPK, apoptosis, and cell cycle pathways [14,15,16,17,18].