In a mouse model of NASH, hepatic mRNA expression of tumor necrosis factor-α (TNF-α), interleukin-6, fatty acid synthesis-related genes, and peroxisome proliferator-activated receptor-α decreased significantly after treatment with hydrogen-rich water (HRW), and the oxidative stress biomarker 8-hydroxydeoxyguanosine in the liver tissue was reduced [23]. The gene discussed is TNF; the disease is metabolic dysfunction-associated steatohepatitis.