GATA3 and Increased total eosinophil count: IFN-γ has incompatible functions; it acts as a stimulator and activates Th1 cell transcription factor (T-bet), and as a suppressor, it activates Th2 cell transcription factor (GATA-3), preventing eosinophilia and inhibiting asthmatic changes such as airway hyperreactivity, inflammation, and mucous hypersecretion in the respiratory system [31,32].