Repression of miR-29s expression via AKT and MYC pathways is associated with a loss of apoptosis and several B-cell malignancies, particularly lymphomas; the oncogenic transcription factor MYC was shown to regulate the expression of all miR-29 family members by binding the promoter region of miR-29b-1/a and decreasing promoter activity by 50% [45]. This evidence concerns the gene MYC and lymphoma.