On the other hand, during the advanced passages of cellular transformation, the RNA-binding protein heterogeneous nuclear ribonucleoprotein L (HNRNPL) binds to the polymorphic marker D2S1888 at the 3′UTR of the BUB1 mitotic checkpoint serine/threonine kinase (BUB1) gene, hampers miR-155 targeting, and allows for the expansion and stabilization of most suitable clones in CLL [122,123]. The gene discussed is HNRNPL; the disease is B-cell chronic lymphocytic leukemia.