These miRNAs induced downregulation of genes such as the Zinc finger and BTB domain containing 4 (ZBTB4) and the Tumor Protein p53 Inducible Nuclear Protein 1 (TP53INP1), which regulate apoptosis through the Cyclin-Dependent Kinase inhibitor 1A (CDKN1A) and TP53 [85], and activated MYC pathways, strongly suggesting an associative interaction between MYC and miR-17-92 in CLL. This evidence concerns the gene ZBTB4 and B-cell chronic lymphocytic leukemia.