Recently, the onco-embryonic surface protein Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1) has been identified as a novel target of miR-15a/16-1; this protein was found to be over-expressed in more than 90% of CLL patients, and its overexpression was associated with high levels of BCL-2 and low levels of miR-15a/16-1 [38]. Here, ROR1 is linked to B-cell chronic lymphocytic leukemia.