Two hotspot point variants at the TERT promoter region, located at −124 (C>T) and −146 (C>T) base pairs (bp) upstream of the translation start site, also referred to as C228T and C250T, activate TERT promoter activity and gene transcription in cancer [8,9], and are identified in TC with aggressive behavior, mainly when coexisting with BRAFV600E [10]. Here, TERT is linked to cancer.