Considering that most reports have focused on the individual role of BRAF [4], TERT [19], HLA-G [14], and miRNAs [18] in PTC, in the present study, we aimed to investigate the individual and collaborative role of BRAF (tumor expression and tumor BRAFV600E status), TERT (tumor TERT status), and HLA-G (tumor and plasma expression), as well as miRNAs (tumor expression) targeting the HLA-G, BRAF and/or TERT genes in the context of PTC malignancy. The gene discussed is HLA-G; the disease is neoplasm.