We identified differentially expressed miRNAs present in the PTC microenvironment that (i) target the BRAF, TERT, and/or HLA-G genes, (ii) are involved in important cancer associated-signaling pathways in PTC pathogenesis, and (iii) at least in part, may explain the increased expression of these genes/proteins in the tumor milieu. The gene discussed is BRAF; the disease is cancer.