ALB and cerebrotendinous xanthomatosis: Two independent studies indeed observed that secretome, and in particular EVs from amniotic fluid stem cells (hAFS), dampen muscle inflammation, counteracting the development of necrotic muscle fibers in a mouse model of muscular atrophy (HSA-Cre, SmnF7/F7 mice) [41] and are able to enhance proliferation, and protect against cellular senescence in the CTX mouse model [42].