CVD risk than the cholesterol-related lipids such as LDL-C and HDL-C [8], we cannot rule out that different factors, rather than visceral adiposity (WC), chronic low-grade inflammation (CRP), and insulin-resistance (HOMA-IR), might affect CERT1, being pathophysiologically involved in the dysregulation of ceramide metabolism in obesity and metabolic syndrome;. The gene discussed is CRP; the disease is metabolic syndrome.