Finally, while the present study revealed an association between CERT1 and CVD risk (e.g., VA), particularly in metabolic syndrome, it will be a highly interesting topic for future investigations to establish whether ceramide composition within the diet of BWRPs (or uniquely weight loss) may result in a reduction of CERT1 and, consequently, CVD risk (or produce other non-CVD-related benefits) in subjects with obesity [6]. This evidence concerns the gene CERT1 and obesity due to melanocortin 4 receptor deficiency.