In our study, considering the anti-inflammatory effects of KLF4 in different tissues [31,32,33], and that mononuclear cell infiltration was reduced upon miR-25 TuD delivery in our histological data, we hypothesized that miR-25 inhibition may also alleviate cardiac inflammation in the context of Ang II-induced cardiac hypertrophy. The gene discussed is KLF4; the disease is cardiac hypertrophy.