ACTA1 and asthma: The role of the EMT process in airway remodelling and subepithelial fibrosis in asthma has been further confirmed by the study of Johnson et al. [95], that in a transgenic murine model sensitised to HDM showed that large airway epithelial cells progressively lost their typical features, acquiring the expression of mesenchymal markers, such as vimentin, α-SMA and type I pro-collagen.