In CF genome, three single-nucleotide polymorphisms in the TGF-β gene at position −509 (C or T; promoter region), +869 (T or C; codon 10 leucine or proline) and +915 (G or C; codon 15 arginine or proline) were identified [268,269,270]. This evidence concerns the gene TGFB1 and cystic fibrosis.