Several individual markers were shown to be very promising for CRC detection, such as SEPTIN9, EHD3, TMEM240, SMAD3, and NTRK3. The panels of abnormally methylated genes have been constructed to increase the sensitivity of the test, namely, BCAT1, IKZF1, and IRF4; SEPTIN9 and HLTF; CLDN1, INHBA, and SLC30A10; EYA4, GRIA4, ITGA4, and MAP3K14-AS1; DLX5, FGF5, FOXF1, BCAT1, COL4A2, GRASP, IKZF1, IRF4, SDC2, FOXI2, and SOX21 (Table 2). Here, SMAD3 is linked to colorectal carcinoma.