FGF2 and idiopathic pulmonary fibrosis: This is interesting, as our previous reports showed increased levels of both bFGF and TNF-alpha in the supernatants of IPF HLF and IPF-CM cultures [41], and that nintedanib, which blocks the FGF receptor (FGFR), was shown to have a significant impact in the IPF-CM system [15,16].